Aspirin + Vitamin C

Oral
Fever, Mild to moderate pain

Gastric or duodenal ulcers. Haemophilia, thrombocytopenia or other bleeding tendencies; patients receiving anti-coagulant treatment. Hypersensitivity to aspirin or other salicylates or ascorbic acid. Severe renal impairment.

Risk of Reye's syndrome in children with varicella infection or influenza-like illnesses. Not to be used for >10 days without medical advice. Treatment should be withdrawn 1 wk prior to surgery to prevent or reduce risk of bleeding complications. Caution when used in patients with impaired renal function, severe hepatic impairment, history of GI disorders e.g. peptic ulcers, ulcerative colitis and Crohn's disease, dyspepsia and when the patient is dehydrated. Pregnancy and lactation.

Dizziness, GI irritation e.g. dyspepsia, nausea, vomiting, erosion, ulceration, haematemesis and melaena. Prolonged use of high doses of aspirin may cause anaemia, blood dyscrasia, GI haemorrhage and peptic ulceration.

Overdose of aspirin can lead to dizziness, tinnitus, sweating, nausea, vomiting, altered glucose metabolism, mental confusion, hyperventilation, respiratory alkalosis, metabolic acidosis, ketosis, fluid and electrolyte losses. CNS depression may lead to coma, CV collapse and respiratory failure. Overdosage of vitamin C may lead to diarrhoea and GI disturbances. Treatment includes gastric lavage, forced alkaline diuresis, restoration of fluid, electrolyte and acid balance, dialysis and supportive therapy may be needed.

Aspirin may increase hypoprothrombinemic effect of warfarin and other oral anticoagulants, thus increasing the risk of bleeding complications. May antagonise uricosuric effect of probenecid, phenylbutazone or sulfinpyrazone. Concurrent admin with corticosteroids may reduce the serum levels of aspirin. Aspirin may increase serum levels of methotrexate. Concurrent admin with alcohol increases risk and severity of GI bleeding and ulceration. Aspirin may reduce the absorption of vitamin C.

May falsely elevate results for blood creatinine, urate (low dose aspirin) and urea and falsely decrease results for blood thyroxine, urate and urinary 5-hydroxyindoleacetic acid (with nitrosonapthol method). Urinary vanillylmandelic acid (or 4-hydroxy-3-methoxymandelic acid) levels may be falsely increased or decreased depending on the method of analysis.

Description:
Mechanism of Action: Aspirin has pain-relieving, anti-pyretic and anti-inflammatory actions. Vitamin C is a water-soluble vitamin that is used with aspirin for the relief of pain and/or fever associated with colds and flu.
Pharmacokinetics:
Absorption: Vitamin C: Readily absorbed via oral admin.
Metabolism: Vitamin C: Hepatic via oxidation and sulfation.

Store below 25°C.

Analgesics (Non-Opioid) & Antipyretics